Prednisone is a synthetic dehydrated analogue of hydrocortisone - the hormone of the adrenal cortex. Affects protein's and carbohydrate's metabolism and in a lesser power metathesis of water and salt. Contributes to growing of glucose in blood, accumulation of glycogen in the liver, increases the excretion of nitrogen in urine, leading to the development of eosin- and lymphopenia, neutropenia. Glucocorticoids render antiallergic, desensitizing, anti-inflammatory, anti-toxic, antishock influence. Anti-inflammatory effect is caused by inhibition of metabolism of arachidonic acid and release of inflammatory mediators. The drug has immunosuppressive effect.
Indications for use:
Systemic diseases of connective tissue (systemic lupus erythematosus , dermatomyositis and polymyositis, systemic vasculitis, rheumatoid arthritis); acute rheumatic fever, rheumatic heart disease; Addison's disease; acute adrenal insufficiency; adrenogenital syndrome; asthma; acute and chronic allergic diseases (drug allergy, serum sickness, urticaria, angioedema); hepatitis; hepatic coma; hypoglycemic states; kidney disease of autoimmune nature; diseases of the blood (agranulocytosis, various forms of leukemia, thrombocytopenic purpura, hemolytic anemia); Hodgkin's disease; skin diseases ( pemphigus, eczema, exfoliative dermatitis, psoriasis, Lyell's syndrome); purulent keratitis, iritis, iridocyclitis, uveitis, choroiditis; pediatric indications: acute rheumatic fever, chorea, asthma, nephrotic syndrome.
Dosage and administration:
Tablets are taken perorally with or without food.
It is administered for an start dose of 20-40 mg/day, then dose is reducing to maintenance dose of 5-10 mg/day (abrupt discontinuation of the remedy may cause exacerbation). Treatment should be stopped only by gradual dose reduction. Maximum dosage for adults: single - 0,015 grams, daily - 0.1 grams. Duration of reception depends on the nature of the disease, its severity, the achieved effect of the drug.